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Hotels in Cape Girardeau

October 2026
November 2026

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Oct 2 - Oct 4
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Oct 9 - Oct 11

Where to stay in Cape Girardeau?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Cape Girardeau on Hotels.com. These Cape Girardeau hotels consistently deliver on quality, location and traveller experience. Last updated on September 27, 2026.
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
P6,247
P7,047 total
includes taxes & fees
Oct 1 - Oct 2
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
P6,310
P7,182 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A spacious living room with a sofa set, a coffee table, and a dining area.
A lobby with seating areas, a reception desk, and a bar.

3. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
P7,816
P8,856 total
includes taxes & fees
Oct 5 - Oct 6
Courtyard by Marriott Cape Girardeau Downtown
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

4. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
P6,609
P7,455 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

5. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
P6,319
P7,129 total
includes taxes & fees
Oct 4 - Oct 5
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A hotel room with two beds, a desk, a chair, and a view of the city.

6. The Riverview

The Riverview
Cape Girardeau
P7,141
P8,056 total
includes taxes & fees
Sep 28 - Sep 29
The Riverview
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

7. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
P4,498
P5,074 total
includes taxes & fees
Oct 4 - Oct 5
Pear Tree Inn Cape Girardeau West
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

8. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
P5,685
P6,413 total
includes taxes & fees
Oct 1 - Oct 2
Drury Inn & Suites Cape Girardeau
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

9. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
P5,584
P6,355 total
includes taxes & fees
Oct 4 - Oct 5
Tru By Hilton Cape Girardeau
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

10. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
P3,742
P4,222 total
includes taxes & fees
Oct 4 - Oct 5
Quality Inn Cape Girardeau North
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

11. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
P4,686
P5,474 total
includes taxes & fees
Sep 27 - Sep 28
Town House Inn Cape Giradreau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.
A hotel room with a bed, a TV, a desk, and a chair.

12. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
P5,333
P6,362 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
A hotel room with two beds, a nightstand, a lamp, and a chair.
An outdoor patio with tables and chairs, a stone wall, and large windows.

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
P5,257
P5,690 total
includes taxes & fees
Sep 27 - Sep 28
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A hotel room with two beds, a brick wall, and a wooden headboard.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A restaurant with a brick wall, a flat-screen TV, and a bar area.

14. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
P5,247
P5,548 total
includes taxes & fees
Oct 11 - Oct 12
Drury Inn & Suites Jackson MO
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.
A room with large windows, two red upholstered chairs, a small table, and a potted plant.

15. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
P4,726
P5,115 total
includes taxes & fees
Oct 22 - Oct 23
Comfort Suites Jackson-Cape Girardeau
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

16. Town House Inn

Town House Inn
Jackson
P4,453
P4,819 total
includes taxes & fees
Sep 27 - Sep 28
Town House Inn
A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.
A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.
A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.
A stone building with a patio area, string lights, and outdoor seating.

17. Makanda Inn

Makanda Inn
Makanda
P16,364
P18,655 total
includes taxes & fees
Sep 27 - Sep 28
Makanda Inn
A living room with a blue wall, a fireplace, a sofa, and a chair.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A bar area with stools and a counter where a bartender is serving drinks.
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

18. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
P6,569
P7,150 total
includes taxes & fees
Oct 4 - Oct 5
EC Reed's Mercantile and Hotel
View all properties

Check out pet-friendly hotels in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
P6,247
P7,047 total
includes taxes & fees
Oct 1 - Oct 2
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
P4,498
P5,074 total
includes taxes & fees
Oct 4 - Oct 5
Pear Tree Inn Cape Girardeau West
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
P5,685
P6,413 total
includes taxes & fees
Oct 1 - Oct 2
Drury Inn & Suites Cape Girardeau
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
P5,584
P6,355 total
includes taxes & fees
Oct 4 - Oct 5
Tru By Hilton Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
P6,609
P7,455 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.
A hotel room with a bed, a TV, a desk, and a chair.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
P5,333
P6,362 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
P4,686
P5,474 total
includes taxes & fees
Sep 27 - Sep 28
Town House Inn Cape Giradreau
View all properties

You may also like hotels with pools in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
P6,247
P7,047 total
includes taxes & fees
Oct 1 - Oct 2
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
P5,685
P6,413 total
includes taxes & fees
Oct 1 - Oct 2
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
P6,310
P7,182 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
P5,584
P6,355 total
includes taxes & fees
Oct 4 - Oct 5
Tru By Hilton Cape Girardeau
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
P6,319
P7,129 total
includes taxes & fees
Oct 4 - Oct 5
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
P6,609
P7,455 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.
A hotel room with a bed, a TV, a desk, and a chair.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
P5,333
P6,362 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
P3,742
P4,222 total
includes taxes & fees
Oct 4 - Oct 5
Quality Inn Cape Girardeau North
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Go beyond your typical stay in Cape Girardeau

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Pet friendly
Pet friendly
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Pool
Pool
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Hot tub
Hot tub
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Spa
Spa
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Family friendly
Family friendly
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Cottage
Cottage
Our prices for hotels in Cape Girardeau are cheapest in January

Price trends for hotels in Cape Girardeau

Pricing is based on two traveler single night rates
View properties in September

September

High 28°C / low 17°C. Sunny most days.
28°
17°
21°
11°
13°
4°
9°
1°
6°
-2°
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14°
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19°
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32°
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Monthly weather averages (˚C)

Top landmarks in Cape Girardeau

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
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A cable-stayed bridge over a river with a rocky shoreline in the foreground.

Riverfront Bridge Park

8.8/10 (129 reviews)
Riverfront Bridge Park is worth a visit, located 0.7 mi (1.1 km) from central Cape Girardeau.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Century Casino & Hotel Cape Girardeau is 0.5 mi (0.8 km) from central Cape Girardeau, why not stop by during your stay.
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Hunter Valley Winery

7.4/10 (48 reviews)
Travelers might want a tour of Hunter Valley Winery, just one of the places to visit, and located 9.3 mi (14.9 km) from central Cape Girardeau.
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Riverfront Park

8.0/10 (2 reviews)
Riverfront Park is worth a visit when in central Cape Girardeau.
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Show Me Center

8.6/10 (40 reviews)
You can catch an event at Show Me Center, located 1.1 mi (1.8 km) from central Cape Girardeau.
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Cape Splash Family Aquatic Center

8.6/10 (21 reviews)
Why not give yourself a treat with a trip to Cape Splash Family Aquatic Center, one of the family attractions located 3.1 mi (5.1 km) from central Cape Girardeau. If you have fun at Cape Splash Family Aquatic Center, you'll love Cape Girardeau Conservation Nature Center, located nearby.
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Cape Rock Park

8.6/10 (36 reviews)
Cape Rock Park is worth a visit, located 1.9 mi (3.1 km) from central Cape Girardeau.
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Learn more about Cape Girardeau

Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Center or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic downtown invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.

See all hotels in Cape Girardeau
A nighttime view of a bridge with its cables illuminated against a starry sky.

Frequently Asked Questions

Can I book a refundable hotel in Cape Girardeau?

If you need the flexibility to change your travel plans to Cape Girardeau, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Cape Girardeau if I want a vacation rental instead of a hotel?

If you want a good alternative to a hotel, look over our selection of 30 vacation homes. In addition, you can choose from 20 apartments.

What will the weather in Cape Girardeau be like during my vacation?

July and August are typically the warmest months in Cape Girardeau when the average temp is 76°F. January and February are the coldest months when the average temperature is 40°F. April and March are the months with the most rain.

Why should I book my Cape Girardeau hotel through Hotels.com?

There are lots of reasons to book your Cape Girardeau trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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