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Hotels in Cape Girardeau

November 2026
December 2026

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Next weekend
Oct 23 - Oct 25
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Oct 30 - Nov 1

Where to stay in Cape Girardeau?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Cape Girardeau on Hotels.com. These Cape Girardeau hotels consistently deliver on quality, location and traveller experience. Last updated on October 18, 2026.
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
P5,983
P6,810 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
P6,297
P7,104 total
includes taxes & fees
Oct 22 - Oct 23
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A spacious living room with a sofa set, a coffee table, and a dining area.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A lobby with seating areas, a reception desk, and a bar.

3. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
P7,879
P8,928 total
includes taxes & fees
Oct 28 - Oct 29
Courtyard by Marriott Cape Girardeau Downtown
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

4. The Riverview

The Riverview
Cape Girardeau
P7,199
P8,121 total
includes taxes & fees
Oct 19 - Oct 20
The Riverview
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
An outdoor patio with stone walls, wicker furniture, and large windows.

5. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
P6,662
P7,516 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn Cape Girardeau I 55 East
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

6. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
P5,668
P6,394 total
includes taxes & fees
Oct 25 - Oct 26
Drury Inn & Suites Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

7. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
P4,534
P5,115 total
includes taxes & fees
Oct 25 - Oct 26
Pear Tree Inn Cape Girardeau West
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

8. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
P6,370
P7,187 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

9. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
P5,629
P6,407 total
includes taxes & fees
Oct 25 - Oct 26
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
A hotel room with a bed, a TV, a desk, and a chair.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

10. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
P4,535
P5,462 total
includes taxes & fees
Nov 1 - Nov 2
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

11. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
P3,747
P4,227 total
includes taxes & fees
Nov 1 - Nov 2
Quality Inn Cape Girardeau North
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A bathroom with a marble wall and a white bathtub.

12. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
P4,409
P5,150 total
includes taxes & fees
Oct 19 - Oct 20
Town House Inn Cape Giradreau
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
An outdoor patio with tables and chairs, a stone wall, and large windows.

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
P5,032
P5,446 total
includes taxes & fees
Nov 1 - Nov 2
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.
A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.
A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.

14. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
P4,764
P5,156 total
includes taxes & fees
Nov 8 - Nov 9
Comfort Suites Jackson-Cape Girardeau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A restaurant with a brick wall, a flat-screen TV, and a bar area.

15. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
P5,038
P5,326 total
includes taxes & fees
Nov 1 - Nov 2
Drury Inn & Suites Jackson MO
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.
Exterior

16. Town House Inn

Town House Inn
Jackson
P4,489
P4,858 total
includes taxes & fees
Oct 19 - Oct 20
Town House Inn
A living room with a blue wall, a fireplace, a sofa, and a chair.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A bar area with stools and a counter where a bartender is serving drinks.
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

17. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
P6,622
P7,208 total
includes taxes & fees
Oct 19 - Oct 20
EC Reed's Mercantile and Hotel
A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.
A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.
A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.
A stone building with a patio area, string lights, and outdoor seating.

18. Makanda Inn

Makanda Inn
Makanda
P16,497
P18,806 total
includes taxes & fees
Oct 19 - Oct 20
Makanda Inn
View all properties

Check out pet-friendly hotels in Cape Girardeau

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
P5,668
P6,394 total
includes taxes & fees
Oct 25 - Oct 26
Drury Inn & Suites Cape Girardeau
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
P6,297
P7,104 total
includes taxes & fees
Oct 22 - Oct 23
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
An outdoor patio with stone walls, wicker furniture, and large windows.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
P6,662
P7,516 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn Cape Girardeau I 55 East
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
P4,534
P5,115 total
includes taxes & fees
Oct 25 - Oct 26
Pear Tree Inn Cape Girardeau West
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
P5,629
P6,407 total
includes taxes & fees
Oct 25 - Oct 26
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
A hotel room with a bed, a TV, a desk, and a chair.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
P4,535
P5,462 total
includes taxes & fees
Nov 1 - Nov 2
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A bathroom with a marble wall and a white bathtub.

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
P4,409
P5,150 total
includes taxes & fees
Oct 19 - Oct 20
Town House Inn Cape Giradreau
View all properties

You may also like hotels with pools in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
P6,297
P7,104 total
includes taxes & fees
Oct 22 - Oct 23
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
P5,668
P6,394 total
includes taxes & fees
Oct 25 - Oct 26
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
P5,983
P6,810 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
P6,370
P7,187 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
An outdoor patio with stone walls, wicker furniture, and large windows.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
P6,662
P7,516 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn Cape Girardeau I 55 East
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
P5,629
P6,407 total
includes taxes & fees
Oct 25 - Oct 26
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
A hotel room with a bed, a TV, a desk, and a chair.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
P4,535
P5,462 total
includes taxes & fees
Nov 1 - Nov 2
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
P3,747
P4,227 total
includes taxes & fees
Nov 1 - Nov 2
Quality Inn Cape Girardeau North
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Go beyond your typical stay in Cape Girardeau

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Family friendly
Family friendly
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Spa
Spa
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Cottage
Our prices for hotels in Cape Girardeau are cheapest in January

Price trends for hotels in Cape Girardeau

Pricing is based on two traveler single night rates
View properties in October

October

High 21°C / low 11°C. Sunny most days.
21°
11°
13°
4°
9°
1°
6°
-2°
8°
-1°
14°
5°
19°
9°
25°
15°
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32°
21°
31°
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28°
17°
Monthly weather averages (˚C)

Top landmarks in Cape Girardeau

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
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A cable-stayed bridge over a river with a rocky shoreline in the foreground.

Riverfront Bridge Park

8.8/10 (129 reviews)
Riverfront Bridge Park is worth a visit, located 0.7 mi (1.1 km) from central Cape Girardeau.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Century Casino & Hotel Cape Girardeau is 0.5 mi (0.8 km) from central Cape Girardeau, why not stop by during your stay.
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Hunter Valley Winery

7.4/10 (48 reviews)
Travelers might want a tour of Hunter Valley Winery, just one of the places to visit, and located 9.3 mi (14.9 km) from central Cape Girardeau.
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Riverfront Park

8.0/10 (2 reviews)
Riverfront Park is worth a visit when in central Cape Girardeau.
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Show Me Center

8.6/10 (40 reviews)
You can catch an event at Show Me Center, located 1.1 mi (1.8 km) from central Cape Girardeau.
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Cape Splash Family Aquatic Center

8.6/10 (21 reviews)
Why not give yourself a treat with a trip to Cape Splash Family Aquatic Center, one of the family attractions located 3.1 mi (5.1 km) from central Cape Girardeau. If you have fun at Cape Splash Family Aquatic Center, you'll love Cape Girardeau Conservation Nature Center, located nearby.
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eDen Spa & Salon

7.8/10 (25 reviews)
If massages and hot tubs are your thing, you might want to pamper yourself at eDen Spa & Salon located 0.4 mi (0.6 km) from central Cape Girardeau.
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Learn more about Cape Girardeau

Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Center or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic downtown invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.

See all hotels in Cape Girardeau
A nighttime view of a bridge with its cables illuminated against a starry sky.

Frequently Asked Questions

Can I book a refundable hotel in Cape Girardeau?

If you need the flexibility to change your travel plans to Cape Girardeau, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Cape Girardeau if I want a vacation rental instead of a hotel?

If you want a good alternative to a hotel, look over our selection of 30 vacation homes. In addition, you can choose from 20 apartments.

What will the weather in Cape Girardeau be like during my vacation?

July and August are typically the warmest months in Cape Girardeau when the average temp is 76°F. January and February are the coldest months when the average temperature is 40°F. April and March are the months with the most rain.

Why should I book my Cape Girardeau hotel through Hotels.com?

There are lots of reasons to book your Cape Girardeau trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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