Hotels in Mytilene

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Mytilene?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Mytilene on Hotels.com. These Mytilene hotels consistently deliver on quality, location and traveller experience. Last updated on November 10, 2026.

1. Hotel Lesvion

Hotel Lesvion
3.0 star property
Lesvos
9.4 out of 10, Exceptional, (147 reviews)
Surrounded by picturesque views, this Lesvos retreat sits minutes from cultural attractions like the Ecclesiastical Byzantine Museum. Grab a drink at the bar or enjoy meals at the restaurant with room service available. Nearby shops, restaurants, and local nightlife complete your Greek island adventure.
The price is P4,444
P4,974 total
includes taxes & fees
Nov 16 - Nov 17
Hotel Lesvion

2. Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
4.0 star property
Lesvos
9.6 out of 10, Exceptional, (176 reviews)
Immerse yourself in paradise at this Lesvos gem with a seasonal outdoor pool and rejuvenating spa services. Just 10 minutes from Port of Mytilene, the hotel offers a rooftop terrace, poolside bar, hot tub, and sauna for ultimate relaxation.
The price is P6,937
P7,810 total
includes taxes & fees
Nov 22 - Nov 23
Theofilos Paradise Boutique Hotel

3. Heliotrope Hotels

Heliotrope Hotels
4.0 star property
Lesvos
8.6 out of 10, Excellent, (203 reviews)
Unwind at this coastal haven with a seasonal outdoor pool and children's splash area. Just 4 minutes from Mytilene Airport, near Teriade Museum, the hotel offers 4 bars, 2 restaurants, and poolside refreshments with free breakfast, WiFi, and parking.
The price is P5,368
P6,091 total
includes taxes & fees
Nov 10 - Nov 11
Heliotrope Hotels

4. Loriet Hotel

Loriet Hotel
4.0 star property
Lesvos
8.4 out of 10, Very good, (96 reviews)
This beach aparthotel offers an outdoor pool with poolside bar, free breakfast, and apartments with premium bedding. Just 4 minutes from Mytilene International Airport, you're near Teriade and Theophilos Museums while enjoying free WiFi and parking.
The price is P5,022
P5,712 total
includes taxes & fees
Dec 1 - Dec 2
Loriet Hotel

5. Akti Vigla Premium

Akti Vigla Premium
Lesvos
10.0 out of 10, Exceptional, (26 reviews)
The price is P3,258
P3,605 total
includes taxes & fees
Nov 22 - Nov 23
Akti Vigla Premium

6. Elysion Hotel

Elysion Hotel
5.0 star property
Lesvos
9.2 out of 10, Wonderful, (51 reviews)
Discover seaside elegance at this luxurious Lesvos retreat near Kochylia. Enjoy 3 tennis courts, multiple pools, and 2 restaurants with refreshing drinks at the bars. Free breakfast, WiFi and parking complete your perfect beach getaway.
The price is P6,572
P7,480 total
includes taxes & fees
Nov 10 - Nov 11
Elysion Hotel

7. Elies Residences

Elies Residences
Lesvos
9.8 out of 10, Exceptional, (38 reviews)
Unwind in a tranquil villa featuring a private kitchen and cozy fireplace. The outdoor pool offers a refreshing escape, while the spa provides rejuvenating facials. Explore nearby Kochylia and the Olive Oil Museum with easy access from this serene garden sanctuary.
The price is P6,927
P7,623 total
includes taxes & fees
Nov 10 - Nov 11
Elies Residences

8. Heliotrope The Studios

Heliotrope The Studios
Lesvos
9.0 out of 10, Wonderful, (62 reviews)
Discover a peaceful Lesvos retreat near Theophilos Museum. Each studio comes equipped with washing machines and refrigerators for added convenience. Enjoy free WiFi and room service while exploring nearby cultural attractions.
The price is P5,965
P6,569 total
includes taxes & fees
Nov 10 - Nov 11
Heliotrope The Studios

9. Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
5.0 star property
Lesvos
8.6 out of 10, Excellent, (74 reviews)
Embrace seaside serenity at this Lesvos luxury retreat offering 5 restaurants and multiple pools. The spa provides indulgent massages while beach amenities await outside. Near Museum of Industrial Olive Oil Production with free breakfast, WiFi and parking.
The price is P5,764
P6,795 total
includes taxes & fees
Nov 22 - Nov 23
Mythical Coast Wellness Retreat

10. Agora Apartments

Agora Apartments
Lesvos
10.0 out of 10, Exceptional, (5 reviews)
Discover comfortable accommodations at this air-conditioned guesthouse within 15 minutes' walk of the Port of Mytilene. Enjoy free WiFi while exploring nearby Theophilos Museum. Convenient access to Mytilene International Airport just 15 minutes away by car.
The price is P4,488
P4,952 total
includes taxes & fees
Nov 14 - Nov 15
Agora Apartments

11. Oikies Small Elegant Houses

Oikies Small Elegant Houses
Lesvos
9.4 out of 10, Exceptional, (30 reviews)
Bask in Mediterranean charm at this Lesvos guesthouse featuring a refreshing outdoor pool with dedicated bar. Free breakfast, convenient room service, and lush garden spaces create a tranquil retreat just moments from cultural highlights like Teriade Museum.
The price is P6,413
P7,061 total
includes taxes & fees
Nov 10 - Nov 11
Oikies Small Elegant Houses

12. Galazio Asteri I

Galazio Asteri I
Lesvos
10.0 out of 10, Exceptional, (17 reviews)
The price is P3,848
P4,250 total
includes taxes & fees
Nov 10 - Nov 11
Galazio Asteri I

13. Paradisos studios

Paradisos studios
Lesvos
9.6 out of 10, Exceptional, (5 reviews)
Unwind at this tranquil Lesvos guesthouse offering free WiFi and parking. Garden surroundings create a peaceful atmosphere while Thermi Beach and the Archaeological Site are just moments away for cultural exploration and seaside relaxation.
The price is P2,078
P2,311 total
includes taxes & fees
Nov 10 - Nov 11
Paradisos studios

14. Olive Green Studios and Apartments

Olive Green Studios and Apartments
Lesvos
10.0 out of 10, Exceptional, (6 reviews)
Escape to this serene Lesvos hotel offering rejuvenating massages and a welcoming beach bar. Comfortable studios feature refrigerators and microwaves, while the garden and terrace provide peaceful relaxation spots near Old Soap Factory.
The price is P4,909
P5,413 total
includes taxes & fees
Nov 10 - Nov 11
Olive Green Studios and Apartments

15. Kaloni village apartments

Kaloni village apartments
Lesvos
8.6 out of 10, Excellent, (8 reviews)
Escape to Lesvos at this beachside retreat near Skala Kallonis Beach and Iera Moni Limonos. After swimming in the outdoor or children's pool, grab a bite at the restaurant or snack bar. Rooms include convenient refrigerators and microwaves.
The price is P4,040
P4,615 total
includes taxes & fees
Nov 10 - Nov 11
Kaloni village apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Get last-minute hotel deals in Mytilene and save more

Sign in to unlock great savings.
Showing deals for:Nov 13 - Nov 15
Showing deals for:Nov 20 - Nov 22

Check out pet-friendly hotels in Mytilene

You can also stay at hotels with a pool in Mytilene

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Go beyond your typical stay in Mytilene

Top landmarks in Mytilene

Learn more about Mytilene

Notable for its seaside, Mytilene features attractions such as Port of Mytilene and Mytilini Castle.

A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Frequently Asked Questions

Can I book a refundable hotel in Mytilene?

If you need the flexibility to change your travel plans to Mytilene, most properties offer refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Mytilene if I want a vacation home instead of a hotel?

If you want a good alternative to a hotel, look over our selection of 15 vacation homes. You can also book one of 23 apartments or 22 villas.

What will the weather in Mytilene be like during my vacation?

The warmest months in Mytilene are usually August and July with an average temp of 77°F. January and February are the chilliest months when the average temp is 52°F. The rainiest months are January and December.

Why should I book my Mytilene hotel through Hotels.com?

There are plenty of reasons to book your Mytilene travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Mytilene

Discover Mytilene: A Tapestry of Ancient Ruins and Coastal Serenity

Nestled on the enchanting island of Lesvos, Mytilene beckons with its rich tapestry of history and culture. This vibrant city boasts stunning beaches, where golden sands meet the azure Aegean Sea. Explore the majestic Mytilene Castle, offering panoramic views and a glimpse into the past. The Archaeological Museum of Mytilene houses remarkable artefacts, while the bustling port serves as a lively hub for local life. Stroll through charming streets filled with quaint shops and delightful eateries, perfect for indulging in the island's culinary delights. Mytilene is an off-the-beaten-path gem, promising a blend of relaxation, culture, and adventure.

Discover great hotels near Mytilene

Mytilene offers a range of accommodations from cosy guesthouses to comfortable hotels with quality beds, ideal for a relaxing stay in Lesvos. The local hotels provide a blend of modern amenities and traditional charm in the North Aegean Islands. Here are some of the most popular hotels with our travelers near Mytilene:

  1. Ariadnes Holiday Accommodationopens in new window: This 3.0-star hotel delights leisure travellers with a superb guest rating and a focus on a beach vacation experience. Enjoy the charm of direct beach access and a guesthouse ambience that exudes comfort and style. Ideal for those seeking a relaxed, high-quality journey, this property combines a welcoming setting with the appeal of a boutique retreat. The contemporary design and express check-in set the stage for a memorable stay, making it a perfect pick for discerning vacationers.
  2. Ariadnes Holiday Accommodation IIopens in new window: This 3.0-star hotel caters to leisure travellers looking for an exceptional beach vacation experience. With an impressive guest rating, the property offers direct access to the beach and an environment that exudes both charm and elegance. Guests can enjoy a curated experience featuring stylish amenities and a refined atmosphere, complete with high-end restaurant options and a sophisticated setting that speaks to the modern explorer.
  3. Aeolis Apartments & Studiosopens in new window: This 3.0-star hotel is designed for leisure travellers who appreciate a distinctive hot spring themed escape. With a generous guest rating, the property stands out for its natural hot spring access and full spa services that include massage, facial treatments, and an inviting pool area with sun loungers. The emphasis on a luxurious spa experience, coupled with express check-in and curated treatments, ensures an indulgent and rejuvenating stay.

Where to stay in Mytilene

In Neapoli, Lesvos, Varia, each locale offers distinct charms: Neapoli boasts inviting beaches, island vibes and warm locals; Lesvos tempts with museums, ruins and luxury, highlighted by Molyvos Castle; and Varia delights with seaside cafes, live music and scenic dining. For first-time visitors, Lesvos is best suited with its balanced blend of attractions and amenities.

  1. Lesvosopens in new window: Lesvos is a fantastic choice for travellers looking to immerse themselves in rich history and stunning landscapes. With its blend of museums, ancient ruins, and charming small towns, you can wander through the picturesque streets and discover local culture. Don’t miss the beautiful Molyvos Castle and the rejuvenating Eftalou Hot Springs, perfect for relaxation after a day of exploring. For beach lovers, the sandy shores are inviting, making it easy to unwind by the sea. There’s plenty of luxury accommodation options available, ensuring a comfortable stay as you enjoy everything this diverse island has to offer.
  2. Variaopens in new window: Varia is an enchanting spot known for its scenic beauty and warm, friendly atmosphere. Nestled by the sea, it’s a perfect place for those who appreciate coffee culture, live music, and relaxing dining experiences. You can take leisurely walks along the coast and enjoy picturesque views while soaking in the local vibe. With museums nearby, there's also an opportunity to delve into the island’s artistic heritage. The laid-back ambiance makes it a great choice for those looking to escape the hustle and bustle while still being close to the action.
  3. Neapoliopens in new window: Neapoli is a hidden gem for those seeking a friendly, beach-focused getaway. With its beautiful coastline and welcoming locals, this area is ideal for travellers wanting to relax by the sea and enjoy the sun. The beaches here are perfect for swimming and sunbathing, making it a favourite for families and couples alike. The charming vibe and slower pace allow you to truly unwind and connect with the island life. It’s the perfect base for exploring nearby attractions while enjoying the friendly hospitality that Neapoli has to offer.

Things to do in Mytilene

Mytilene offers a blend of dramatic coastal cliffs, lush parks, and intriguing historical ruins. Enjoy strolls along scenic beaches, explore verdant forested areas, and discover a charming port town steeped in tradition.

  • Teriade Museumopens in new window – Discover a treasure trove of contemporary art at Teriade Museum. This unique venue showcases a variety of exhibitions that delve into modern artistic expression, making it a delightful stop for art enthusiasts. Explore its collection and appreciate the creativity that flourished in this cultural hub.
  • Molyvos Castleopens in new window – Climb to the top of Molyvos Castle for breathtaking views of the surrounding landscape and the Aegean Sea. This historic fortress, with its impressive architecture, invites you to wander through its ancient corridors and imagine the stories of the past. Don't miss the stunning sunset from this vantage point.
  • Mólyvosopens in new window – Spend a relaxing day at Mólyvos, where you can bask on the sandy beach or take a leisurely stroll along the picturesque waterfront. The charming village atmosphere, lined with traditional tavernas and shops, creates a perfect backdrop for a day of exploration and relaxation.
  • Eftalou Hot Springsopens in new window – Unwind in the soothing waters of Eftalou Hot Springs, known for their therapeutic properties. Immerse yourself in the warm, mineral-rich waters while soaking in the beautiful coastal scenery. It's a refreshing way to rejuvenate after a day of sightseeing.
  • Monastery of Saint Raphaelopens in new window – Visit the serene Monastery of Saint Raphael, a place of spiritual significance and stunning architecture. Take a moment to reflect in the peaceful surroundings, and admire the intricate designs and beautiful frescoes that adorn this sacred site.

4 tips for savvy savings when booking a hotel in Mytilene

  1. Book for the cheapest times: Visiting Mytilene on a budget can be a great value for money, especially during February, November, and December, when hotel prices may drop to lower prices. A stay of at least 4 to 5 days is ideal for exploring the key landmarks, historical sites, and cultural attractions such as museums, a castle, monuments, ruins, islands, a marina, a port, churches, the sea, and notable architecture. This affordable period offers budget-friendly opportunities to discover the rich history and vibrant culture of the area.
  2. Look for last-minute deals on Hotels.com: For hotel deals in Mytilene, begin by exploring Dealsopens in new window on Hotels.com, where you may discover discounted rates on hotels near your travel dates. Additionally, the Last-Minute Deals section could help you find reduced prices if you're booking close to your departure. For further ease, the Smart Shopping tool available via the app allows you to compare hotel prices and amenities, ensuring you're more likely to see the best offers for Mytilene hotel deals. Sign up for email alerts or push notifications to stay informed about any flash sales and opportunities to save.
  3. Be flexible with dates: Prices may differ depending on factors like the hotel's location, star rating, and the time of year, so being flexible with your dates might help you save on your stay in Mytilene hotel. For those seeking a unique experience, boutique hotels often offer a more personalised stay and occasionally better value. When you book with Hotels.com, we will advise you if the price for your chosen dates is above or below the average, and if it appears to be on the higher side, we may suggest more affordable dates to help you find a better deal.
  4. Consider your location: Remaining near major attractions or city centres can be convenient but usually tends to be more expensive. For more affordable options, consider hotels in less central areas or neighbourhoods, balancing cost with accessibility to your planned destinations. You might also explore independent hotels further afield, which can offer a more authentic and budget-friendly experience.

Best time to go to Mytilene

Mytilene experiences its lowest average temperature in January, at 49.3°F (9.6°C), while August is the hottest month, with an average temperature of 80.1°F (26.7°C). January is typically the wettest month. If you’re looking to soak up the lively atmosphere in Mytilene, July to September are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is sunny, with no rainfall. However, if you prefer a more relaxed experience, January, February, and December are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.

Keep exploring