Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Cairo on Hotels.com. These Cairo hotels consistently deliver on quality, location and traveler experience. Last updated on .
Hotels in Cairo

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1. Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
Harrah's Metropolis Hotel & Casino - A Caesars Rewards DestinationMetropolis
8.4 out of 10, Very good, (1,004 reviews)
$117 nightly
The price is $130
Dec 13 - Dec 14
Total with taxes and fees

2. The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (704 reviews)
$106 nightly
The price is $120
Nov 29 - Nov 30
Total with taxes and fees

3. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,004 reviews)
$100 nightly
The price is $113
Nov 15 - Nov 16
Total with taxes and fees

4. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,002 reviews)
$94 nightly
The price is $108
Nov 22 - Nov 23
Total with taxes and fees

5. Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
$90 nightly
The price is $102
Nov 22 - Nov 23
Total with taxes and fees

6. Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.2 out of 10, Wonderful, (1,004 reviews)
$72 nightly
The price is $81
Nov 22 - Nov 23
Total with taxes and fees

7. Quality Inn Cairo I-57
Quality Inn Cairo I-57Cairo
6.4 out of 10, Good, (297 reviews)
$70 nightly
The price is $78
Dec 4 - Dec 5
Total with taxes and fees

8. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
$95 nightly
The price is $108
Dec 13 - Dec 14
Total with taxes and fees

9. Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (659 reviews)
$101 nightly
The price is $115
Nov 22 - Nov 23
Total with taxes and fees

10. Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (562 reviews)
$116 nightly
The price is $132
Nov 22 - Nov 23
Total with taxes and fees

11. Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHGCape Girardeau
8.0 out of 10, Very good, (1,001 reviews)
$69 nightly
The price is $83
Nov 25 - Nov 26
Total with taxes and fees

12. Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
8.4 out of 10, Very good, (1,009 reviews)
$70 nightly
The price is $80
Dec 14 - Dec 15
Total with taxes and fees

13. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (242 reviews)
$86 nightly
The price is $97
Nov 29 - Nov 30
Total with taxes and fees

14. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very good, (831 reviews)
$67 nightly
The price is $76
Nov 15 - Nov 16
Total with taxes and fees

15. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (118 reviews)
$110 nightly
The price is $125
Nov 19 - Nov 20
Total with taxes and fees

16. Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MOCharleston
6.8 out of 10, Good, (686 reviews)
$59 nightly
The price is $66
Dec 1 - Dec 2
Total with taxes and fees

17. Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham SikestonSikeston
7.4 out of 10, Good, (1,001 reviews)
$66 nightly
The price is $76
Nov 15 - Nov 16
Total with taxes and fees

18. Eagle Inn Charleston
Eagle Inn CharlestonCharleston
6.6 out of 10, Good, (107 reviews)
$66 nightly
The price is $74
Nov 14 - Nov 15
Total with taxes and fees

19. Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.8 out of 10, Excellent, (527 reviews)
$95 nightly
The price is $108
Dec 13 - Dec 14
Total with taxes and fees

20. Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 EastCape Girardeau
9.6 out of 10, Exceptional, (861 reviews)
$98 nightly
The price is $110
Nov 22 - Nov 23
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Cairo
Pet friendly
Top landmarks in Cairo
Learn more about Cairo
Cairo is well-known for its attractions such as Mississippi River and Ohio River Valley. The city has something for everyone including sights like Fort Defiance State Park within a small-town setting.

Check out reviews of Cairo hotels guests love

Super 8 by Wyndham Charleston/Sikeston East MO
8/10 Good
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