The location of the hotel is hard to beat, but please be aware while it may be listed as 4 stars, it's really closer to a 3 star US hotel.
The rooms need some updating, there's a weird musky odor and the AC is not very strong, and neither are the beds super comfortable.
BUT what the hotel and rooms lack the hotel staff and location more than make up for. Breakfast was always served quickly and the staff was very friendly. The front desk was very helpful with helping to arrange a last minute tour/driver as well as allowing us to leave our luggage. They provide a free tuk-tuk transfer from the airport which was a lifesaver.
As for location, it's literally within less than 5 minutes from pub street and the night market in a smaller less busy street. BUT please be aware that is is located right next to a school, so in the early morning and evening (since in Cambodia they have day students and afternoon students) you can here the kids yelling and playing in the background, even with the windows and doors all shut.