Hotels in Cayo Guillermo

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Free cancellation

Flexible bookings on most hotels*

Where to stay in Cayo Guillermo?

Find out more about Cayo Guillermo

If you're looking for a place to get away, look no further than Cayo Guillermo. Whether you're planning to stay for a night or for the week, the area around Cayo Guillermo has accommodations to fit every need. Search for hotels in Cayo Guillermo with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Cayo Guillermo hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Cayo Guillermo hotel deals are here with our lowest price guarantee.

Frequently asked questions

What accommodations do travelers recommend in Cayo Guillermo?
Guests like Hotel Grand Muthu Cayo Guillermo, Iberostar Daiquirí - All inclusive and Sol Cayo Guillermo - All Inclusive.
Where can I get free parking with my stay in Cayo Guillermo?
Villa Gregorio offers the perk of free parking.
Can I book a refundable accommodation in Cayo Guillermo?
If you want the flexibility to change your travel plans to Cayo Guillermo, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Cayo Guillermo?
Your furry friend can stay with you at this pet-friendly hotel: Sol Cayo Guillermo - All Inclusive.
Where should I stay in Cayo Guillermo if I want a cheap accommodation?
An inexpensive option worth considering is Villa Gregorio.
Where can I stay if I'm visiting Cayo Guillermo with my children?
Your kids are welcome at Hotel Grand Muthu Cayo Guillermo and Villa Gregorio.
Where should I stay in Cayo Guillermo if I want a luxury hotel?
An option for a luxury stay is Iberostar Daiquirí.
What will the weather in Cayo Guillermo be like during my vacation?
With an average temperature of 75°F during the coldest months, Cayo Guillermo is a great place to visit any time of year.
Why should I book my Cayo Guillermo accommodation with Hotels.com?
There are plenty of reasons to book your Cayo Guillermo travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, our Price Guarantee makes sure you always get the lowest price, and our Rewards Program lets you earn reward nights and save cash.