Hotels in Cayo Santa Maria

Free cancellation options if plans change
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Check prices for these dates

Tonight
Mar 15 - Mar 16
Tomorrow
Mar 16 - Mar 17
Next weekend
Mar 21 - Mar 23
In two weeks
Mar 28 - Mar 30

Where to stay in Cayo Santa Maria?

Learn more about Cayo Santa Maria

If you're wanting to unwind at the beach, look no further than Playa Las Gaviotas in the area.

See all hotels in Cayo Santa Maria

Frequently asked questions

Can I book a refundable hotel in Cayo Santa Maria?
If you want the flexibility to change your plans to Cayo Santa Maria, most hotels offer refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay if I'm visiting Cayo Santa Maria for a family-friendly trip?
Parents traveling with children may want to consider Grand Memories Santa Maria - All Inclusive.
What will the weather in Cayo Santa Maria be like during my vacation?
With an average temperature of 75°F during the coldest months, Cayo Santa Maria is a great place to visit any time of year.
Why should I book my Cayo Santa Maria hotel through Hotels.com?
There are lots of reasons to book your Cayo Santa Maria trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.